Lineas de investigacion

Non extractable polyphenols, antioxidants and dietary fiber in health (POLIFIBAN)


The activity of the research team is focused on the study of certain bioactive compounds present in foods of vegetal origin, such as dietary fibre and polyphenols. As distinctive feature, the team studies non-extractable polyphenols or macromolecular antioxidants, as a particular class of these compounds widely distributed in foods and with promising health effects. The research team is based on a global approach to the study of the selected compounds, comprising determination of their content in foods, evaluation of in vitro effects through several antioxidant capacity techniques, studies of bioavailability in humans and study of acute and chronic health effects, with a specific approach towards cardiometabolic diseases.


  • Determination of non extractable polyphenols in food and diets.
  • Determination of dietary fibre in foods and diets
  • Study of properties and health effects of non extractable polyphenols.
  • Design and development of nutritional clinical trials.
  • Design of functional ingredients and foods, especially from food byproducts or underexploited raw materials.

Research Lines

  • Non extractable polyphenols
  • Dietary fiber
  • Diet and cardiometabolic diseases


  • Antioxidant capacity methodology in food and diets
  • Design and nutritional evaluation of dietary fiber and functional ingredients
  • Human trails for evaluation of effects of bioactive compounds, including metabolomics.


  • Patent WO 2017013299 A1. Saura-Calixto F, Pérez-Jiménez J. “Method for producing a concentrate of polymer proanthocyanidins with a concentration of more than 40% by means of enzymatic treatments and without using organic solvents”.


Group Leader:



  • 91 549 23 00


polyphenols, Antioxidants, Dietary fiber, Diet, Functional ingredients, Functional Food


  • Pérez-Ramírez I, Reynoso-Camacho R, Saura-Calixto F, Pérez-Jiménez J. 2018. Comprehensive characterization of extractable and non-extractable phenolic compounds by HPLC-ESI-QTOF of a grape/pomegranate pomace dietary supplement. J. Agric. Food Chem., 66, 661-73.

    Pérez-Jiménez J, Saura-Calixto F. 2018. Fruit peels as sources of non-extractable polyphenols or macromolecular antioxidants: analysis and nutritional implications. Food Res. Intl., 111, 148-52.

    Martínez-Maqueda D, Zapatera B, Gallego-Narbón A, Vaquero MP, Saura-Calixto F, Pérez-Jiménez J. 2018. A 6-weeks supplementation with grape pomace to subjects at cardiometabolic risk ameliorated insulin sensitivity, without affecting other cardiometabolic parameters. Food Function, 9, 6010-19.

    Amaya-Cruz D, Pérez-Ramírez I, Pérez-Jiménez J, Nava GM, Reynoso-Camacho R. 2019. Comparison of the bioactive potential of Roselle (Hibiscus sabdariffa L.) calyx and its by-product: phenolic characterization by UPLC-QTOF MSE and their anti-obesity effect in vivo.  Food Res. Intl., ID 108589.

    Ramos-Romero S, Martínez-Maqueda D, Hereu M, Amézqueta S, Torres JL, Pérez-Jiménez J. 2020. Modifications of gut microbiota after grape pomace supplementation in subjects at cardiometabolic risk: a randomized cross-over controlled clinical trial. Foods, 9, 1279-91.

    Gutiérrez-Díaz I, Salazar N, Pérez-Jiménez J, De los Reyes-Gavilán CG, Gueimonde M, González S. In press. New players in the relationship between diet and microbiota: the role of macromolecular antioxidant polyphenols. Eur. J. Nutr.

PhD Thesis, Master's Thesis and Degree Thesis

Display PhD Thesis, Master's Thesis and Degree Thesis

Tesis Doctoral: Design and assessment of a dietary supplement, from agricultural byproducts, for the prevention of cardiovascular risk factors (2018)

Author: Diana Amaya Cruz / Director: Rosalía Reynoso Camacho y Jara Pérez Jiménez

Institution: Universidad Autónoma de Querétaro, México