Bacterial biotechnology
(BIOBACT)

Home » Research Teams » Bacterial biotechnology (BIOBACT)

The research in bacterial biotechnology contributes, by the use of functional genomics and biotechnological processes, to generate quality knowledge useful for the identification and the development of bacterial strains, enzymes, and metabolites to improve the food elaboration processes or the microbial functionality in hosting organisms.

Research Lines

  • Identification, characterization, and genetic improvement of bacteria present in food substrates.
  • Identification, characterization, production, and improvement of enzymes with technological interest.
  • Development of biochemical and molecular methods for the detection of relevant bacterial traits.
  • Systems Biology studies aimed at improving the functionality of bacteria in food processes and host-microbial interactions.

Skills

  • Biochemical and molecular techniques for the detection of bacteria and genes with technological interest.
  • Production and purification of recombinant enzymes.
  • Genetic expression analysis.

Patents

  • Procedimiento bi-enzimático de síntesis eficiente de oligosacáridos fructosilados derivados de lactosacarosa, productos obtenidos y su uso en la mejora de la salud gastrointestinal.
  • Author(s): Francisco Javier Moreno, Marina Diez, Miguel Herrero, Nieves Corzo, Rosario Muñoz, Blanca de las Rivas y María Luisa Jimeno.
  • Date: 2014
  • Number: P201430784
  • Licensed: No
  • Degradación biológica de ocratoxina A en ocratoxina alfa.
  • Author(s): Rosario Muñoz Moreno, Blanca de las Rivas González del Rey, Héctor Rodríguez López, Inés Reverón Poján, Emilia García-Moruno, Francesca Doria y Antonella Costantini.
  • Date: 2010
  • Number: PCT/WO2012/025657A1
  • Licensed: No
  • Uso de bacterias lácticas para conservar los flavanoles de un producto alimenticio y prevenir el pardeamiento del vino.
  • Author(s):Félix López de Felipe Toledano, Rosario Muñoz Moreno y José Antonio Curiel Gámiz.
  • Date: 2010
  • Number: PCT/WO201151494A1
  • Licensed: No

BIOBACT Leader:

Scientific Personnel:

Technical personnel:

Contact:

Publications

  • Reverón, I., Jiménez, N., Curiel, J.A., Peñas, E., López de Felipe, F., de las Rivas, B., Muñoz, R.
    “Differential gene expression by Lactobacillus plantarum WCFS1 in response to phenolic compounds reveals new genes involved in tannin degradation” Appl. Environ. Microbiol. (2017) 83:e03387-16.
  • https://doi.org/10.1128/AEM.03387-16
  • Reverón, I., Plaza-Vinuesa, L., Franch, M., de las Rivas, B., Muñoz, R., López de Felipe, F.
    “Transcriptome-based analysis in Lactobacillus plantarum WCFS1 reveals new insights into resveratrol effects at system level” Mol. Nutr.Food Res. (2018) 62:1700992
  • https://doi.org/10.1002/mnfr.201700992
  • Santamaría, L., Reverón, I., López de Felipe, F., de las Rivas, B., Muñoz, R.
    “Ethylphenols formation by Lactobacillus plantarum: Identification of the enzyme involved in vinylphenol reduction” Appl. Environ. Microbiol. (2018) 84:e01064-18.
  • https://doi.org/10.1128/AEM.01064-18
  • Esteban-Torres, M., Santamaría L, Cabrera-Rubio, R., Plaza-Vinuesa L, Crispie, F., de las Rivas, B., Cotter, P., Muñoz, R. “A diverse range of human gut bacteria have the potential to metabolize the dietary component gallic acid” Appl. Environ. Microbiol. (2018) 84:e01558-18.
  • https://doi.org/10.1128/AEM.01558-18
  • Plaza-Vinuesa, L., Hernández-Hernández, O., Moreno, F. J., de las Rivas, B., Muñoz, R.
    “Unraveilling the diversity of glycoside hydrolase family 13 α-amylases from Lactobacillus plantarum WCFS1” Microb Cell Fact. (2019) 18:183.
  • https://doi.org/10.1186/s12934-019-1237-3
  • Reverón, I., Plaza-Vinuesa, L., Santamaría, L., Oliveros, J. C., de las Rivas, B., Muñoz, R, López de Felipe, F. “Transcriptomic evidence of molecular mechanisms underlying the response of Lactobacillus plantarum WCFS1 to hydroxytyrosol” Antioxidants (2020) 9:442.
  • https://doi.org/10.3390/antiox9050442

Projects, Contracts, Agreements

F.E.D.E.R

PhD Thesis, Master’s Thesis and Degree Thesis

PhD Thesis