Polyphenols and health

Home » Research Teams » Polyphenols and health (POLYHEALTH)

Our objective is the study of nutritional factors that allow healthy aging and that improve the quality of life of the elderly. More specifically, we want to delve into the study of the beneficial health properties of dietary polyphenols. For this we focus both on the study of its bioavailability and metabolism as well as its action at various levels, mainly cardiometabolic, neuronal and visual.

Research Lines

  • Dietary polyphenols and healthy aeging.
  • Interaction of polyphenols with other Food bioactives or micronutrients.
  • Food ingredients and Food products with neuroregulatory activity.


  • Cellular models of inflammation, endotelial function, intestinal absorption, hepathic metabolsim, retina and neuronal function.
  • Nutritional studies in healthy population.
  • Chromatographic techniques (HPLC-DAD, LC-MS, Qtof and QQQ) for polyphenol analysis,  metabolomics, fatty acids and bille acids and salts in different products and biological samples.
  • Antioxidant activiy in Foods, biological products and cellular models.
  • Biochemistry analysis (ELISA, enzimatc activities,  etc) and molecular biology (Western-blot and RT-PCR).


  • Uso de hidrolizados de proteínas lácteas como protectores a nivel gastrointestinal.
  • Author(s): Mª Isidra Recio Sánchez, Mª Angeles Beatriz Miralles Buraglia, Daniel Martinez Maqueda, Blanca Hernández Ledesma; Sonia Cristina de Pascual-Teresa Fernández, Lourdes Amigo Garrido, Mª del Rocio Girón Moreno, Carlos Goicoechea García.
  • Date: 2012
  • Number: PCT/ES12/031227
  • Licensed: No
  • Procedimiento de obtención de compuestos antimicrobianos activos contra Campylobacter spp. a partir de mostos de Vitis vinífera y/o productos provenientes de su fermentación.
  • Author(s): Adolfo Martínez Rodríguez,Elisa Mingo Fernández, Jose Manuel Silván Jiménez, Alfonso Carrascosa Santiago, Sonia de Pascual-Teresa Fernández.
  • Date: 2011
  • Number: PCT/ES11/031604
  • Licensed: No




  • Silvan, J.M.; Reguero, M.; de Pascual-Teresa, S. Protective effect of anthocyanins and xanthophylls on UVB-induced damage in retinal pigment epithelial cells. Food Func. 7, 1067-1076 (2016).
  • https://doi.org/10.1039/c5fo01368b
  • Granda, H.; de Pascual-Teresa, S. Polyphenols interaction with other food components as a mean for their neurological health benefits. J. Agric. Food Chem 66(31):8224-8230 (2018).
  • https://doi.org/10.1021/acs.jafc.8b02839
  • Estévez-Santiago, R.; Silván, J.M.; Can-Cauich, C.A.; Veses, A.M.; Alvarez-Acero, I.; Martinez-Bartolome, M.A.; San Román R.; Olmedilla-Alonso, B.; de Pascual-Teresa, S. Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women. Nutrients, 11(7), 1533226 (2019).
  • https://doi.org/10.3390/nu11071533
  • Eker, M.E.; Kjersti, A.; Budic-Leto, I.; Rimac-Brncic, S.; El, S.N.; Karakaya, S.; Simsek, S.; Manach, C.; Wiczkowski, W.; de Pascual-Teresa, S. A review of factors affecting anthocyanin bioavailability: possible implications for the interindividual variability. Foods 9(1):2 (2020).
  • https://doi.org/10.3390/foods9010002
  • Pallauf, K.; Günther, I.; Kühn, G.; Chin, D.; de Pascual-Teresa, S.; Rimbach, G. Can resveratrol be considered as caloric restriction mimetic? – Insights from studies in mice. Adv. Nutr, in press (2021).
  • https://doi.org/10.1093/advances/nmaa148
  • Chamorro, S.; Cueva-Mestanza, R.; de Pascual-Teresa, S. Effect of spray drying on the polyphenolic compounds present in purple sweet potato roots: Identification of new cinnamoylquinic acids. Food Chem., in press (2021).
  • https://doi.org/10.1016/j.foodchem.2020.128679