Bioactive compounds (polyphenols, methylxanthines, prebiotics) form vegetable foods (phytochemicals) play a crucial role in consumer`s health, although not the individual response of each person may differ. The reasons for this interindividual variability include the different capacity to absorb and metabolize these compounds, genetic and epigenetic factors of each person (nutri(epi)genetics) or life style, among other factors.
The group BIOCELL studies the bioavailability of plant phytochemicals, the mechanisms of action of these compounds and their metabolites, the involvement of the intestinal microbiota in the response to their consumption, and the activity of phytochemicals on non-communicable chronic diseases like diabetes, obesity or cardiovascular disease, with a focus on personalized nutrition.
The research methodology is based on experiments in cell culture, preclinical research in different animal models, and performing intervention clinical trials in humans, both in healthy volunteers and persons at risk.
Bioactive compounds, Polyphenols & phytochem, Oxidative stress, Bioavailability, Cell signalling pathways, Intervention studies