Home » ICTAN Members » Tomás Herraiz

Tomás Herraiz Tomico

Research Scientist

Research Groups: Bioactive molecules and biotransformation (MOLBIOTRANS)

Department: Characterization, Quality and Safety Department

Short Bio

T. Herraiz has a PhD in Chemistry (Biochemistry) from the Complutense University of Madrid. After a period of work at the University of California, Davis (USA), he obtained a position as Scientist (CSIC), and later as Scientific Researcher (CSIC). His research is mainly dedicated to study the bioactive compounds and their molecular biotransformation into new bioactive and/or toxic species. He has published numerous publications and original works on beta-carbolines in foods and plants, and their formation and biological activity as well as on their metabolism by oxidoreductase enzymes. TH is author of about 100 scientific publications, with an h index (google-scholar) of 39. He is a reviewer of more than 50 different scientific journals belonging to several research areas, and a reviewer of national and international research funding agencies.

Herraiz, T.; Peña, A.; Salgado, A. Identification, formation, and occurrence of perlolyrine: A β-Carboline alkaloid with a furan moiety in foods. J. Agric. Food Chem. 71(36),13451–61 (2023).

https://doi.org/10.1021/acs.jafc.3c03612

Herraiz T. β-Carboline alkaloids in soy sauce and inhibition of monoamine oxidase (MAO). Molecules. 28(6), 2723 (2023).

https://doi.org/10.3390/molecules28062723

Herraiz, T.; Peña, A.; Mateo, H.; Herraiz, M.; Salgado, A. Formation, characterization, and occurrence of β-carboline alkaloids derived from α-dicarbonyl compounds and L-tryptophan. J. Agric. Food Chem. 70(29), 9143–53 (2022).

https://doi.org/10.1021/acs.jafc.2c03187

Herraiz, T; Vera, F. Occurrence, formation from D-fructose and 3-deoxyglucosone, and activity of the carbohydrate-derived β-carbolines in foods. J. Agric. Food Chem.69(23), 6650–64 (2021).

https://doi.org/10.1021/acs.jafc.1c02281

Herraiz, T.; Guillen, H. ; González-Peña, D. ; Arán, V.J. Antimalarial quinoline drugs inhibit beta-hematin and increase free hemin catalyzing peroxidative reactions and inhibition of cysteine proteases. Scientific Reports 9, 15398 (2019).

https://doi.org/10.1038/s41598-019-51604-z

Manzano, J.I.; Cueto-Diaz, E.J.; Olias-Molero, A.I.; Perea, A.; Herraiz, T.; Torrado, J.J. ; Alunda, J.M.; Gamarro, F.; Dardonville, C. Discovery and pharmacological studies of 4-hydroxyphenyl-derived phosphonium salts active in a mouse model of visceral Leishmaniasis. J. Med.Chem 62, 10664-10675 (2019).

https://doi.org/10.1021/acs.jmedchem.9b00998

Development of new antiparasitic drugs targeting DNA duplexes and quadruplexes (DNA-Q4cure).
Reference: PID2022-136438OB-I00.
IP y co-IP: C. Dardonville (IQM-CSIC); A. Gomez-Barrio, UCM
Duration: 1/09/2023 to 31/08/2027.
Funding entity: AEI-Cofinanciado UE.
In vivo safety and efficacy of a new entity for the oral treatment of veterinary leishmaniasis (VetLesihCure).
Reference: PDC2022-133269-I00.
IP y co-IP: C. Dardonville (IQM-CSIC).
Duration: 1/12/2022 to 30/11/2024.
Funding entity: AEI-UE-Next Generation.
Novel therapeutic strategies for the treatment of degenerative disorders based on the endocannabinoid system.
Reference: PID2021-127833OB-I00
Duration: 1/08/2022 to 31-08-2025.
IP y co-IP: N. Jagerovic (IQM-CSIC); A. Castro Morera, IQM-CSIC.
Funding entity: AEI-Cofinanciado UE.

915492300 ext. 436421

therraiz@ictan.csic.es

ORCID:
0000-0003-3682-9227

Researcher ID:
K-9958-2014

Scopus Author ID:
7003467477