Metabolismo y bioactividad de fitoquímicos (BIOCELL)
Department: Departamento de Metabolismo y Nutrición
She obtained her B.S. degree in Pharmacy (1994) from the University Complutense of Madrid (UCM), and her PhD in Pharmacy from the same University (1999). Postdoctoral research fellow at the Institute of Biochemistry, CSIC-UCM, Madrid (2000), and in Germany at the institute of Biochemistry I, University of Cologne (1997-1998). Following, she moved to the former Instituto del Frío (CSIC, nowadays ICTAN) as “Ramón y Cajal” researcher in 2003 and was promoted to Tenured Scientist in 2008. Her research activity in the field of nutritional biochemistry is focused on the study of the molecular mechanisms of action of bioactive food components, mainly phenolic compounds and their metabolites, and their potential effect on health and on the prevention of chronic diseases related to the oxidative stress (cancer, diabetes, cardiovascular disease). Her expertise includes development of different experimental approaches in cultured cells, experimental animals (pre-clinical studies), and more recently, human clinical trials both in healthy and risk population groups, with special interest on diabetes and its complications.
Alvarez-Cilleros D, Martín MA, Ramos S. Epicatechin and the colonic 2,3-dihydroxybenzoic acid metabolite regulate glucose uptake, glucose production, and improve insulin signalling in renal NRK-52E cells. Mol. Nutr. Food Res. 62, 1700470 (2018) DOI: 10.1002/mnfr.201700470
Alvarez-Cilleros D, Ramos S, López-Oliva E, Escriva F, Alvarez C, Fernandez-Millan E, Martín MA. Cocoa diet modulates gut microbiota composition and improves intestinal health in Zucker diabetic rats. Food Res. Inter. 132, 109058 (2020). DOI. 10.1016/j.foodres.2020.109058
Dietary high molecular weight flavanols as cardioprotective adjuvants in type 2 diabetes: from their molecular mechanism to their pre-clinical and clinical effects
IP y co-IP: María Ángeles Martín Arribas y Sonia Ramos Rivero
Duración: 01/10/2019 – 31/09/2021
Entidad financiadora: MICINN (con cofinanciación FEDER)
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