Polyphenols and health
(POLYHEALTH)

Home » Research Teams » Polyphenols and health (POLYHEALTH)

Our objective is the study of nutritional factors that allow healthy aging and that improve the quality of life of the elderly. More specifically, we want to delve into the study of the beneficial health properties of dietary polyphenols. For this we focus both on the study of its bioavailability and metabolism as well as its action at various levels, mainly cardiometabolic, neuronal and visual.

Research Lines

  • Dietary polyphenols and healthy aeging.
  • Interaction of polyphenols with other Food bioactives or micronutrients.
  • Food ingredients and Food products with neuroregulatory activity.

Skills

  • Cellular models of inflammation, endotelial function, intestinal absorption, hepathic metabolsim, retina and neuronal function.
  • Nutritional studies in healthy population.
  • Chromatographic techniques (HPLC-DAD, LC-MS, Qtof and QQQ) for polyphenol analysis,  metabolomics, fatty acids and bille acids and salts in different products and biological samples.
  • Antioxidant activiy in Foods, biological products and cellular models.
  • Biochemistry analysis (ELISA, enzimatc activities,  etc) and molecular biology (Western-blot and RT-PCR).

Patents

  • Uso de hidrolizados de proteínas lácteas como protectores a nivel gastrointestinal.
  • Author(s): Mª Isidra Recio Sánchez, Mª Angeles Beatriz Miralles Buraglia, Daniel Martinez Maqueda, Blanca Hernández Ledesma; Sonia Cristina de Pascual-Teresa Fernández, Lourdes Amigo Garrido, Mª del Rocio Girón Moreno, Carlos Goicoechea García.
  • Date: 2012
  • Number: PCT/ES12/031227
  • Licensed: No
  • Procedimiento de obtención de compuestos antimicrobianos activos contra Campylobacter spp. a partir de mostos de Vitis vinífera y/o productos provenientes de su fermentación.
  • Author(s): Adolfo Martínez Rodríguez,Elisa Mingo Fernández, Jose Manuel Silván Jiménez, Alfonso Carrascosa Santiago, Sonia de Pascual-Teresa Fernández.
  • Date: 2011
  • Number: PCT/ES11/031604
  • Licensed: No

POLYHEALTH Leader:

Contact:

Publications

  • Phenolic Characterization of a Purple Maize (Zea mays cv. «Moragro») by HPLC-QTOF-MS and Study of Its Bioaccessibility Using a Simulated In Vitro Digestion/Caco-2 Culture Model. Rodriguez MD, Monsierra L, Mansilla PS, Pérez GT, de Pascual-Teresa S. J Agric Food Chem. 2024 Mar 27;72(12):6327-6338.
  • https://doi.org/10.1021/acs.jafc.3c08960
  • Effects of Polyphenol-Rich Foods on Chronic Diseases. Goya L, de Pascual-Teresa S. Nutrients. 2023 Sep 25;15(19):4134.
  • https://doi.org/10.3390/nu15194134
  • Regular Consumption of Cocoa and Red Berries as a Strategy to Improve Cardiovascular Biomarkers via Modulation of Microbiota Metabolism in Healthy Aging Adults. García-Cordero J, Martinez A, Blanco-Valverde C, Pino A, Puertas-Martín V, San Román R, de Pascual-Teresa S. Nutrients. 2023 May 13;15(10):2299.
  • https://doi.org/10.3390/nu15102299
  • Anti-inflammatory effect of two pomegranate seed oils obtained by green technologies in Caco-2 cells using the bioaccessible fraction from in vitro gastrointestinal digestion. Bañares C, Carballeda-Sangiao N, Chabni A, García-Cordero J, Reglero G, de Pascual-Teresa S, Torres CF. Food Res Int. 2023 Mar;165:112475.
  • https://doi.org/10.1016/j.foodres.2023.112475
  • From Cocoa to Chocolate: Effect of Processing on Flavanols and Methylxanthines and Their Mechanisms of Action. Goya L, Kongor JE, de Pascual-Teresa S. Int J Mol Sci. 2022 Nov 18;23(22):14365.
  • https://doi.org/10.3390/ijms232214365
  • Polyphenols’ Effect on Cerebrovascular Health. Goya L, San Román R, de Pascual-Teresa S. Curr Med Chem. 2022;29(6):1029-1044.
  • https://doi.org/10.2174/0929867328666211129123459
  • Neurocognitive Effects of Cocoa and Red-Berries Consumption in Healthy Adults. García-Cordero J, Pino A, Cuevas C, Puertas-Martín V, San Román R, de Pascual-Teresa S. Nutrients. 2021 Dec 21;14(1):1.
  • https://doi.org/10.3390/nu14010001

Projects, Contracts, Agreements

F.E.D.E.R

European

PhD Thesis, Master’s Thesis and Degree Thesis

Master's Thesis

Degree Thesis