Lineas de investigacion

Polyphenols and health (POLYHEALTH)

Description

Objetives

Our objective is the study of nutritional factors that allow healthy aging and that improve the quality of life of the elderly. More specifically, we want to delve into the study of the beneficial health properties of dietary polyphenols. For this we focus both on the study of its bioavailability and metabolism as well as its action at various levels, mainly cardiometabolic, neuronal and visual.

Research Lines

  • Dietary polyphenols and healthy aeging.
  • IInteraction of polyphenols with other Food bioactives or micronutrients.
  • Food ingredients and Food products with neuroregulatory activity.
Capacidades

Skills

  • Cellular models of inflammation, endotelial function, intestinal absorption, hepathic metabolsim, retina and neuronal function.
  • Nutritional studies in healthy population.
  • Chromatographic techniques (HPLC-DAD, LC-MS, Qtof and QQQ) for polyphenol analysis,  metabolomics, fatty acids and bille acids and salts in different products and biological samples.  
  • Antioxidant activiy in Foods, biological products and cellular models.
  • Biochemistry analysis (ELISA, enzimatc activities,  etc) and molecular biology (Western-blot and RT-PCR).

Patents

  • Use of milk protein hydrolysates as protectors at the gastrointestinal level. PCT/ES12/031227. 2012. Ma Isidra Recio Sánchez, Ma Angeles Beatriz Miralles Buraglia, Daniel Martinez Maqueda, Blanca Hernández Ledesma; Sonia Cristina de Pascual-Teresa Fernández, Lourdes Amigo Garrido, Ma del Rocio Girón Moreno, Carlos Goicoechea García.
  • Procedure for obtaining antimicrobial compounds active against Campylobacter spp. from Vitisvinifera musts and / or products from its fermentation. PCT/ES11/031604. 2011. Adolfo Martínez Rodríguez,Elisa Mingo Fernández, Jose Manuel Silván Jiménez, Alfonso Carrascosa Santiago, Sonia de Pascual-Teresa Fernández.

Personnel

Group Leader:

Members:

Contact:

  • 91 549 23 00 – Ext. 231309
  • s.depascualteresa@csic.es

Keywords

Polyphenol, cell culture, human trial, antioxidant, aeging, prevention

Publications

Silvan, J.M.; Reguero, M.; de Pascual-Teresa, S. Protective effect of anthocyanins and xanthophylls on UVB-induced damage in retinal pigment epithelial cells. Food Func. 7, 1067-1076 (2016). 10.1039/c5fo01368b

Granda, H.; de Pascual-Teresa, S. Polyphenols interaction with other food components as a mean for their neurological health benefits. J. Agric. Food Chem 66(31):8224-8230 (2018). 10.1021/acs.jafc.8b02839

Estévez-Santiago, R.; Silván, J.M.; Can-Cauich, C.A.; Veses, A.M.; Alvarez-Acero, I.; Martinez-Bartolome, M.A.; San Román R.; Olmedilla-Alonso, B.; de Pascual-Teresa, S. Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women. Nutrients, 11(7), 1533226 (2019). 10.3390/nu11071533

Eker, M.E.; Kjersti, A.; Budic-Leto, I.; Rimac-Brncic, S.; El, S.N.; Karakaya, S.; Simsek, S.; Manach, C.; Wiczkowski, W.; de Pascual-Teresa, S. A review of factors affecting anthocyanin bioavailability: possible implications for the interindividual variability. Foods 9(1):2 (2020). 10.3390/foods9010002

Pallauf, K.; Günther, I.; Kühn, G.; Chin, D.; de Pascual-Teresa, S.; Rimbach, G. Can resveratrol be considered as caloric restriction mimetic? – Insights from studies in mice. Adv. Nutr, in press (2021). https://doi.org/10.1093/advances/nmaa148

Chamorro, S.; Cueva-Mestanza, R.; de Pascual-Teresa, S. Effect of spray drying on the polyphenolic compounds present in purple sweet potato roots: Identification of new cinnamoylquinic acids. Food Chem., in press (2021). https://doi.org/10.1016/j.foodchem.2020.128679

Projects, Contracts, Agreements

FEDER projects

Polyphenol-rich foods as a healthy and sustainable aging strategy (KEPHENOL)

Main Researcher: S. de Pascual-Teresa y GP Blanch / Start Date: 06/01/2020 / End Date: 12/31/2024 / Institution: MCIU/AEI/ERDF, EU / Reference number: PID2019-107009RB-I00
Research Group: Innovative Technologies for the Study of Food Bioactive Compounds (ENANTIOMET)


Antocianos y xantofilas: fuentes, mecanismos de acción y efectos en humanos

Main Researcher: PASCUAL-TERESA FERNANDEZ, SONIA CRISTINA DE / Start Date: 01/01/2013 / End Date: 12/31/2015 / Institution: MINECO / Reference number: AGL2012-30803
Research Group: Polyphenols and health (POLYHEALTH)


Dietary anthocyanins and flavanols from food as a strategy for healthy aging: cardiovascular health and cognitive status

Main Researcher: S. C. de Pacual-Teresa / Start Date: 12/30/2016 / End Date: 12/29/2019 / Institution: AEI/ERDF, EU / Reference number: AGL2016-76832-R
Research Group: Polyphenols and health (POLYHEALTH)


PhD Thesis, Master's Thesis and Degree Thesis

Display PhD Thesis, Master's Thesis and Degree Thesis

Trabajo de Fin de Master: Optometry and Vision Msc Thesis Effect of the polyphenols present in red berries on visual function (2019)

Author: Leonor Herguedas Fenoy y Beatriz Sánchez-Gavilán / Director: Maria Cinta Puell Marín y Sonia de Pascual-Teresa Fernández

Institution: Universidad Complutense de Madrid

Trabajo de Fin de Master: Optometry and Vision Msc Thesis: Effect of cocoa consumption on the visual function of adults. (2019)

Author: Lorena Carrasco Herrero y Laura de la Cruz Salamanca / Director: Maria Cinta Puell Marín y Sonia de Pascual-Teresa Fernández

Institution: Universidad Complutense de Madrid

: Sanitary Biology Bsc Degree Thesis: Modulation of intestinal microbiota metabosime by cocoa polyphenols and red berries (2019)

Author: Carlos Blanco Valverde / Director: Sonia de Pascual-Teresa Fernández

Institution: Universidad de Alcalá de Henares

Tesis Doctoral: Sanitary Biology Bsc Degree Thesis: Study of the effect of regular consumption of anthocyanins and flavanols on endothelial function. (2018)

Author: Hugo Granda Pérez / Director: Sonia de Pascual-Teresa Fernández

Institution: Universidad de Alcalá de Henares

Trabajo de Fin de Master: Nutrition and Metabolism interuniversity Msc Thesis: Effect of xanthophylls and anthocyanins on liver (HepG2) and endothelial cells (EAhy 926). (2016)

Author: Natalie Gallegos González / Director: Sonia de Pascual-Teresa Fernández

Institution: Universidad Rovira y Virgili

Trabajo de Fin de Master: Food engineering and health Msc Thesis: Role of antioxidant bioactive compounds against ultraviolet light damage in retinal cells. In vitro cell studies (2015)

Author: Marina Reguero Simón / Director: Sonia de Pascual-Teresa Fernández

Institution: Universidad Politécnica de Madrid