Non extractable polyphenols, antioxidants and dietary fiber in health (POLIFIBAN)

MEMBERS

Group Leader: Jara Pérez Jiménez

Members:

  • Jara Pérez Jiménez – (Tenured Scientist)
  • Ana Veses Alcobendas – (Senior Technician)

Contact: +34 91 5492300 ext. 231223 – jara.perezarrobaictan.csic.es

DESCRIPTION

Objectives:

  • Determination of non extractable polyphenols in food and diets.
  • Study of properties and health effects of non extractable polyphenols.
  • Contribution to nutrional properties of dietary fiber matrix associated compounds
  • Dietary antioxidants: Metabolomics and effects
  • Design of functional ingredients and food

Research Lines:

  • Non extractable polyphenols
  • Antioxidants
  • Dietary fiber
  • Diet and health

Skills:

  • Antioxidant capacity methodology in food and diets
  • Design and nutritional evaluation of dietary fiber and functional ingredients
  • Human trails for evaluation of effects of bioactive compounds, including metabolomics.

Keywords: polyphenols, Antioxidants, Dietary fiber, Diet, Functional ingredients, Functional Food

SCI PUBLICATIONS

  • Pérez-Ramírez I, Reynoso-Camacho R, Saura-Calixto F, Pérez-Jiménez J. Comprehensive characterization of extractable and non-extractable phenolic compounds by HPLC-ESI-QTOF of a grape/pomegranate pomace dietary supplement. J.Agric Food Chem 66:661-73 (2018). DOI: 10.1021/acs.jafc.7b05901.
  • Blancas-Benítez FJ, Pérez-Jiménez J, Montalvo-González E, González-Aguilar GA, Sáyago-Ayerdi SG. In vitro evaluation of the kinetics of the release of phenolic compounds from guava fruit (Psidium guajava L.).  J Funct Foods 43:139-45 (2018). DOI: 10.1016/j.jff.2018.02.011
  • Molinar-Toribio E, Fuguet E, Ramos-Romero S, Taltavull N, Méndez L, Nogués MR, Medina I, Torres JL, Pérez- Jiménez J. A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats. Eur J Nutr 57:339-49 (2018). DOI: 10.1007/s00394-016-1323-9.
  • Nascimento-Souza A, Gontijo de Paiva P, Pérez-Jiménez J, Do Carmo Castro Franceschini S, Queiroz Ribeiro A. Estimated dietary intake and major food sources of polyphenols in elderly of Viçosa, Brazil: a population-based study. Eur J Nutr 57:617-27(2018). DOI: 10.1007/s00394-016-1348-0.
  • Pérez-Jiménez J, Saura-Calixto F. Fruit peels as sources of non-extractable polyphenols or macromolecular antioxidants: analysis and nutritional implications. Food Res Intl 111:148-52 (2018). DOI: 10.1016/j.foodres.2018.05.023.
  • Freire M, Cofrades S, Pérez-Jiménez J, Gómez-Estaca J, Jiménez-Colmenero F, Bou R. Emulsion gels containing n-3 fatty acids and condensed tannins designed as functional fat replacers. Food Res Intl 113:465-73 (2018). DOI: 10.1016/j.foodres.2018.07.041
  • Herranz B, Álvarez MD, Pérez-Jiménez J. Association of plasma and urine viscosity with cardiometabolic risk factors and oxidative status. A pilot study in subjects with abdominal obesity. PLOS One 13:e0204075 (2018). DOI: 10.1371/journal.pone.0204075
  • Martínez-Maqueda D, Zapatera B, Gallego-Narbón A, Vaquero MP, Saura-Calixto F, Pérez-Jiménez J. A 6-weeks supplementation with grape pomace to subjects at cardiometabolic risk ameliorated insulin sensitivity, without affecting other cardiometabolic parameters. Food Func (2018). DOI: 10.1039/C8FO01323C.
  • Sanz-Pintos N, Pérez-Jiménez J, Buschmann AH, Vergara-Salinas JR, Pérez-Correa JR, Saura-Calixto F. Macromolecular antioxidants and dietary fiber in edible seaweeds. J. Food Sci 82:289-95 (2017). DOI: 10.1111/1750-3841.13592.
  • Molinar-Toribio, Ramos-Romero, Fuguet, Taltavull, Méndez, Romeu, Medina,  Torres, Pérez-Jiménez. Influence of omega-3 PUFAs on the metabolism of proanthocyanidins in rats. Food Res Intl 97:133-40 (2017). DOI: 10.1016/j.foodres.2017.03.046
  • Solari-Godiño A, Pérez-Jiménez J, Saura-Calixto F, Borderías AJ, Moreno HM. Anchovy mince (Engraulis ringens) enriched with polyphenol-rich grape pomace dietary fibre: in vitro polyphenols bioaccessibility, antioxidant and physico-chemical properties. Food Res Intl 102:639-46 (2017). DOI:10.1016/j.foodres.2017.09.044.
  • Dasilva G, Pazos M, García-Egido E, Pérez-Jiménez J, Torres JL, Giralt M, Nogués R, Medina I. Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model. Food Chem 205:196-203 (2016). DOI: 10.1016/j.foodchem.2016.03.020.
  • Ramos-Romero S, Molinar-Toribio E, Pérez-Jiménez J, Taltavull N, Dasilva G, Romeu M, Medina I, Torres JL. The combined action of omega-3 polyunsaturated fatty acids and grape proanthocyanidins on a rat model of diet-induced metabolic alterations. Food Func 7:3516-23 (2016). DOI: 10.1039/c6fo00679e.
  • Rothwell JA, Medina-Remón A, Pérez-Jiménez J, Neveu V, Knaze V, Slimani N, Scalbert A. Effects of food processing on polyphenol content: a systematic analysis using Phenol-Explorer data. Molec Nutr Food Res 59:160-70 (2015). DOI: 10.1002/mnfr.201400494.
  • Molinar-Toribio EM, Pérez-Jiménez J, Ramos-Romero S, Romeu M, Giralt M, Taltavull N, Muñoz-Cortés M, Jáuregui O, Méndez L, Medina I, Torres JL. Effects of omega-3 PUFA supplementation at different EPA/DHA ratios on the spontaneously hypertensive obese rats. Br J Nutr 113:878-87 (2015). DOI: 10.1017/S0007114514004437.
  • Molinar-Toribio E, Pérez-Jiménez J, Ramos-Romero S, Gómez L, Taltavull N, Nogués MR, Adeva A, Jáuregui O, Joglar J, Clapés P, Torres JL. D-fagomine attenuates metabolic alterations induced by a high-energy-dense diet in rats. Food Func 6:2614-19 (2015). DOI: 10.1039/C5FO00591D.
  • Pérez-Jiménez J, Díaz-Rubio ME, Saura-Calixto F. Obtainment and characterization of a potential functional ingredient from olive. Int J Food Sci Nutr 66:749-54 (2015). DOI: 10.3109/09637486.2015.1095863.
  • Pérez-Jiménez J, Díaz-Rubio ME, Saura-Calixto F. Contribution of macromolecular antioxidants to dietary antioxidant capacity: a study in the Spanish Mediterranean diet. Plant Foods Human Nutr 70:365-70 (2015). DOI: 10.1007/s11130-015-0513-6.
  • Pérez-Jiménez J, Saura-Calixto F. Macromolecular antioxidants or non-extractable polyphenols in fruit and vegetables: intake in four European countries. Food Res. Intl. 74, 315-23 (2015). DOI: 10.1016/j.foodres.2015.05.007
  • Díaz-Rubio ME, Pérez-Jiménez J, Martínez-Bartolomé MA, Álvarez I, Saura-Calixto F. Regular consumption of an antioxidant-rich juice improves oxidative status and causes metabolome changes in healthy adults. Plant Foods Human Nutr. 70, 9-14 (2015). DOI: 10.1007/s11130-014-0455-4.
  • Pérez-Jiménez J, Díaz-Rubio ME, Mesías M, Morales FJ, Saura-Calixto F. Evidence for the formation of Maillardized insoluble dietary fiber in bread: a specific kind of dietary fiber in thermally processed foods. Food Res Intl 55, 391-96 (2014). DOI: 10.1016/j.foodres.2013.11.031
  • Molinar-Toribio E, Pérez-Jiménez J, Ramos-Romero S, Lluís L, Sánchez-Martos V, Taltavull N, Romeu M, Pazos M, Méndez L, Miranda A, Cascante M, Medina I, Torres JL. Cardiovascular disease-related parameters and oxidative stress in SHROB Rats, a model for metabolic syndrome. PLOS One 9:e104637 (2014). DOI: 110.1371/journal.pone.0104637
  • Pérez-Jiménez J, Díaz-Rubio ME, Saura-Calixto F. Non-extractable polyphenols, a major dietary antioxidant: occurrence, metabolic fate and health effects. Nutr Res Rev. 26, 118-29 (2013). DOI: 10.1017/S0954422413000097
  • Sánchez-Tena S, Lizárraga D, Miranda A, Vinardell MP, García-García F, Dopazo J, Torres JL, Saura-Calixto F, Capella G, Cascante M. Grape antioxidant dietary fiber inhibits intestinal polyposis in ApcMin/+ mice: Relation to cell cycle and immune response. Carcinogenesis 34, 1881-88 (2013). DOI: 10.1093/carcin/bgt140
  • Zurita J, Díaz-Rubio ME, Saura-Calixto F. Improved procedure to determine non-extractable polymeric proanthocyanidins in plant foods. Intl. J. Food Sci. Nutr., 63, 933-39 (2012). DOI: 10.3109/09637486.2012.681634
  • Saura-Calixto F. Concept and health-related properties of nonextractable polyphenols: The missing dietary polyphenols. J. Agric. Food Chem., 60, 11195-12000 (2012). DOI: 10.1021/jf303758j
  • Saura-Calixto F. Dietary fiber as a carrier of dietary antioxidants: an essential physiological function. (Perspective) J. Agric. Food. Chem., 59, 43-40 (2011)
  • Rufino MdSM, Pérez-Jiménez J, Arranz S, Alves RE, de Brito ES, Oliveira MSP, Saura-Calixto F. Açaí (Euterpe oleraceae) ‘BRS Par’: A tropical fruit source of antioxidant dietary fiber and high antioxidant capacity oil. Food Res. Int. 44, 2100-2106 (2011)
  • Diaz Rubio ME, Saura-Calixto F. Beverages have an appreciable contribution to the intake of soluble dietary fibre: a study in the Spanish diet. Int. J. Food Sci Nutr (2011)
  • Díaz Rubio ME, Serrano J, Borderías J, Saura-Calixto F. Technological effect and nutricional value of dietary antioxidante Fucus fiber added to fish mince. J. Aquatic Food Product Technol., 20, 295-307 (2011)
  • Saura- Calixto F, Pérez- Jiménez J, Touriño S, Serrano J, Fuguet E, Torres JL, Goñi I. Proanthocyanidin metabolites associated with dietary fibre from in vitro colonic fermentation and proanthocyanidin metabolites in human plasma. Mol Nutr Food Res 54, 939-946 (2010)
  • Cordenunsi B, Saura-Calixto F, Diaz-Rubio ME, Zuleta A, Tiné MA, Buckeridge MS, Bezerra da Silva G, Carpio C, Gonçalves A, Wenzel de Menezes E, Lajolo F. Carbohydrate composition of ripe pineapple (var. perola) and the glycemic response in humans. Rev Ciencia e Tecnologia de Alimentos , 30, 282-288 (2010)
  • Arranz A, Saura-Calixto F. Analysis of polyhenols in cereals may be improved performing acidic hydrolysis: a study in wheat flour and wheat bran and cereals of the diet. J. Cereal Sci. 51, 305-312 (2010)
  • Rufino MS, Alves RE, de Brito ES, Pérez-Jimenez J, Saura-Calixto F, Mancini-Filo J. Bioactive compounds and antioxidant capacity of 18 non-traditional tropical fruits from Brazil. Food Chem. 121, 996-1002 (2010).
  • Brenes A, Viveros A, Goñi I, Centeno C, Saura-Calixto F, Arija I. Effect of grape extract on growth performance, proptein and polyphenols digestibilities, and antioxidant activity in chickens. Spanish J. Agricultural Res. 8, 326-333 (2010)
  • Silvan JM, Morales FJ, Saura-Calixto F. Conceptual study o Mailardized dietary fiber in coffee. J. Agric. Food Chem. 58, 12244-12249 (2010)
  • Arranz S, Saura-Calixto F. Non extractable polyphenols, ussually ignored, are the major part of dietary polyphenopsl: A study on the Spanish diet. Mol. Nutr. Food Res., 54, 1646-1658 (2010)
  • Rufino MSM, Pérez-Jimenez J, Tabernero M, Alves RE, de Brito RS , Saura-Calixto F. F. Acerola and cashew apple as source of antioxidants and dietary fibre. Int. J. Food Sci. Technol. 45, 2227-2233 (2010)
  • Saura-Calixto F. Antioxidant dietary fibre: a new functional ingredients. Ernahrung/ Nutrition 34, 509-514 (2010)
  • Saura-Calixto F, Goñi I. Definition of the Mediterranean Diet Based on Bioactive Compounds. Crit. Rev. Food Sci Nutr 49(2); 145-152 (2009)
  • Diaz-Rubio ME, Saura-Calixto F. Dietary Fiber Complex in beer . J Am Soc Brewing Chem. 67(1); 38-43 (2009)
  • Goñi I, Díaz-Rubio ME, Pérez-Jiménez J, Saura-Calixto F. Towards an updated methodology for measurement of dietary fiber, including associated polyphenols, in food and beverages. Food Res Internat 42(7); 840- 846 (2009)
  • Díaz-Rubio ME, Pérez-Jiménez J, Saura-Calixto F. Dietary fiber and antioxidant capacity in Fucus vesiculosus products. Internat J Food Sci Nutr, 2; 23-34 (2009)
  • Pérez-Jiménez J, Serrano J, Tabernero M, Arranz, Díaz- Rubio M, García-Diz L, Saura-Calixto F. Bioavailability of phenolic antioxidants associated with dietary fiber. Plasma antioxidant capacity after acute and long-term intake in humans. Plant Foods Hum. Nutr. 64(2); 102-107 (2009)
  • Saura-Calixto F, Pérez-Jiménez J, Goñi I. Contribution of cereals to dietary fibre and antioxidant intakes:toward more reliable methodology, J Cereal Sci, 50 (2); 291-294 (2009)
  • Serrano J, Puupponen-Pimia R, Dauder A,Saura-Calixto F. Tannis: Current knowledge of food sources,intake, bioavailability and biological effects. Mol Nutr Food Res, 53(2), S310-329; (2009)
  • Goni I, Saura-Calixto F. Antioxidant dietary fibre Concept and properties. Agro Food Industry Hi-Tech, 20(3), 20-22 (2009)
  • Rufino MS, Alves RE, Brito ES , Pérez Jimenez J, Saura-Calixto F. Total phenolic content and antioxidant activity in Acerola, Acai, Mangaba and Uvaia by DPPH method. Acta Hortic 841; 459-462 (2009)
  • Pérez-Jiménez J, Arranz S, Saura-Calixto F. Proanthocyanidin content in foods is largely underestimated in the literature data.An approach to quantification of the missing proanthochyanidins. Food Res Internat, 42; 1381-1388 (2009)
  • Arranz S, Saura-Calixto F, Shaha S, Kroon PA. High Contents of Nonextractable Polyphenols in Fruits Suggest That Polyphenol Contents of Plant Foods Have Been Underestimated. J Agric Food Chem, 57(16); 7298-7303 (2009)
  • Pérez-Jiménez J, Saura-Calixto F. Grape products and cardiovascular disease risk factors. Nutr. Res Rev 21(2): 158-173 (2008)
  • Tourino S, Fuguet E, Jauregui O, et al. High-resolution liquid chromatography/ electrospray ionization time-of-flight mass spectrometry combined with liquid chromatography/electrospray ionization tandem mass spectrometry to identify polyphenols from grape antioxidant dietary fiber. Rapid Communications in mass spectrometry, 22 (22): 3489-3500 (2008)
  • Pérez-Jiménez J, Serrano J, Tabernero M, et al. Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. Nutrition 24(7-8): 646-53 (2008)

NON-SCI PUBLICATIONS

  • Pérez-Jiménez J. Antioxidant capacity of non-extractable polyphenols as key dietary parameter. En: Non-extractable polyphenols and carotenoids: importance in human nutrition and health. Editores: F. Saura-Calixto, J. Pérez-Jiménez, RSC, Reino Unido, 263-83 (2018) ISBN: 978-1-78801-106-8.
  • Saura-Calixto F, Pérez-Jiménez J (editors). Non-extractable polyphenols and carotenoids: importance in human nutrition and health. Royal Society of Chemistry, Reino Unido (2018) ISBN: 978-1-78801-106-8.
  • Pérez-Jiménez J. Superalimentos: ¿qué hay de cierto en ellos? Acta Científica y Tecnológica, 28:4-8 (2018)
  • Pérez-Jiménez J, Saura-Calixto F. Dietary fiber and associated macromolecular antioxidants in fruit and vegetable. En: Fruit and vegetable phytochemicals: chemistry and human health. Editores: EM Yahia. Wiley-Blackwell Publishing, Ames, EEUU, 393-404 (2017). ISBN 978-1-119-15794-6.
  • Sáyago-Ayerdi SG, Mercado-Mercado G, Ramos-Romero S, Torres JL, Pérez-Jiménez J. Analysis and characterization of polyphenols extracts.  En: Advances in Technologies for Producing Food-relevant Polyphenols. Editores: J Cuevas-Valenzuela, JR Vergara-Salinas, JR Pérez-Correa. CRC Press, Boca Ratón, USA 193-221 (2016). ISBN- 9781498714976
  • Torres JL, Ramos-Romero S, Pérez-Jiménez J. Key aspects of polyphenols and health: metabolic fate, mechanisms of action, influence on gut microbiota.  En: Advances in Technologies for Producing Food-relevant Polyphenols. Editores: J Cuevas-Valenzuela, JR Vergara-Salinas, JR Pérez-Correa. CRC Press, Boca Ratón, EEUU, 33-62 (2016) ISBN- 9781498714976.
  • Pérez-Jiménez J, Díaz-Rubio ME, Saura-Calixto F. Non-extractable polyphenols in plant foods: nature, isolation and analysis” Capítulo en el libro “Polyphenols in plants. Isolation, purification and extract preparation”. Editor: R. Watson, V.R. Preedy, S. Zibadi. Academic Press-Elsevier, San Diego, USA, 203-18 (2014) ISBN-9780123979346.
  • Pérez-Jiménez J. Aprovechamiento de subproductos de la industria alimentaria ricos en fibra y antioxidantes fenólicos para la obtención de ingredientes funcionales. Alimentaria 446, 72-77 (2013)
  • Saura-Calixto F, Zurita J, Díaz-Rubio ML. Vinos sin alcohol: capacidad antioxidante y contribución a la ingesta de antioxidantes de la dieta. Alimentaria 93-97 (2011).

PROJECTS AND CONTRACTS

  • Potential modulatory effect of whole grape on second-meal tolerance in obese subjects: role of polyphenols. Investigador principal: Jara Pérez Jiménez. 01/09/2018 – 31/08/2019.  Comisión de la uva de Mesa de California, Health Research Grants 2018.
  • Caracterización y aprovechamiento tecnológico de frutas subutilizadas para el desarrollo de alimentos funcionales: evaluación de frutos del género Psidium. Investigador principal: Carolina Rojas Garbanzo. Universidad de Costa Rica. 01/08/2018 – 31/07/2020. Red Temática de la Universidad de Costa Rica.
  • Development of efficient and environmentally friendly processes for the production of safe and bioactive phlorotannins extracts from Chilean seaweeds. Investigador principal: José Ricardo Pérez Correa. Pontificia Universidad Católica, Chile. 01/01/2018 – 31/03/2022. Proyecto del Fondo Nacional de Desarrollo Científico y Tecnológico,  Chile, FONDECyT 1180571.
  • Capacity of Chilean seaweed extracts for selective inhibition of enzymes related with starch digestion and postprandial glycemic response. Investigador principal: Javier Alejandro Parada Silva. Universidad Austral, Valdivia, Chile. 01/04/2017 – 31/03/2020. Proyecto del Fondo Nacional de Desarrollo Científico y Tecnológico, Chile, FONDECyT 1170594.
  • Desarrollo y elaboración de una bebida basada en la dieta mediterránea. Investigador principal: Fulgencio Saura Calixto. 01/01/2016 – 30/11/2016. Contrato de I+D con AMC Grupo Alimentación S.A.
  • Polifenoles (extraíbles y no extraíbles) de uva y granada como moduladores del síndrome metabólico. Estudios en humanos a dosis nutricionales. Investigador principal: Jara Pérez Jiménez. 01/09/2015 – 31/08/2017. MINECO. AGL2014-55102-JIN
  • Desarrollo experimental en la obtención de fibras antioxidantes a partir del orujo de uva (cáscara y semillas) aplicando técnicas de secado en frío para incrementar la vida útil de los productos elaborados a partir de anchoveta para el consumo humano. Investigador Principal: Francisco Javier Borderías, Fulgencio Saura Calixto. 01/11/2013-31/10/2016. FINCyT (Fundación para la Investigación, Ciencia y Tecnología, Perú)
  • Análisis de materias primas derivadas de frutas. Investigador principal: Fulgencio Saura Calixto. 01/12/2013-31/5/2014. Contrato de Apoyo Tecnológico con AMC Grupo Alimentación S.A. 110102140005
  • Algas de Huinay como fuente de florotaninos, compuestos con propiedades biológicas y antioxidantes de interés en biomedicina. Investigador principal: Fulgencio Saura Calixto. 01/01/2013-01/11/2013. CSIC-Endesa-Fundación Huinay. 2013CL018
  • Ingrediente antioxidante de bajo contenido calórico. Procedimiento de obtención y uso. Investigador principal: Fulgencio Saura-Calixto. 01/12/2012-01/06/2013. Contrato de Apoyo Tecnológico con AMC Grupo Alimentación S.A. 110102130008
  • Polifenoles no extraíbles y Fibra Maillardizada en pan: estudio estructural y metabolómico. IP: F.Saura Calixto. 2012-2014. AGL 2011-27741
  • Compuestos polifenolicos no extraibles y compuestos de Maillard en alimentos : propiedades relacionadas con nutricion y salud gastrointestinal . IP: F.Saura Calixto. 2009-2012. Intramural CSIC (ref. 200470E662).
  • Elucidación del papel de complejos dietéticos indigestibles en nutrición y salud. IP: F. Saura Calixto. 2008-2009. AGL-2008-02541.
  • Fibra antioxidante en base a tomate de árbol. (España-Ecuador). IP: F. Saura Calixto y Jenny Ruales. 2008-2010. Proyecto AECI. 013152
  • Análisis y evaluación nutricional de nuevas fuentes de fibra dietética antioxidante. IP: F. Saura Calixto. 2008-2010. Intramural CSIC (ref. 200470E463)
  • Determinación de compuestos bioactivos de frutas de consumo habitual en cuatro países de la Unión Europea. Hero SA. 2007-2008. IP: F Saura Calixto.
  • Chilled baby fruit: influencia del proceso tecnológico sobre la calidad nutricional de productos infantiles de frutas Hero S.A. 2007-2008. IP: F Saura Calixto.

PhD THESIS AND MASTERS

THESIS

  • Compuestos polifenólicos (extraíbles y no extraíbles) en alimentos de la dieta española: Metodología para su determinación. Doctorando: Sara Arranz Martínez. 2010. Director: D. F. Saura Calixto. Universidad Complutense de Madrid
  • Propriedades funcionais des frutas tropicais brasileiras nao tradicionais. Doctorando: Maria do Socorro Moura Rufino. 2009. Directores: Ricardo Elesbao Alves y Fulgencio Saura Calixto. UniversidadeFederal Rural do Semi-Arido UFERSA- Mossoró (Brasil) Embrapa, Fortaleza(Brasil)
  • Fibra dietética y compuestos asociados en dietas mediterránea y escandinava. Doctorando : María Tabernero Urbieta. 2008 Director: F. Saura Calixto. Universidad Complutense de Madrid, Facultad de Ciencias Biológicas
  • Fibra dietética en bebidas de la dieta. Determinación, composición y contribución a la ingesta de fibra Doctoarndo: Mª Elena Díaz Rubio. 2008. Director: F. Saura Calixto. Universidad Autónoma de Madrid, Facultad de Ciencias
  • Metodología para la evaluación de ingrdientes funcionales antioxidantes. Doctorando : Jara Pérez Jiménez. 2007. Director: F. Saura Calixto. Universidad Autónoma de Madrid, Facultad de Ciencias

MASTER

  • Trabajo fin de Máster:  Polifenoles de uva y granada como moduladores del síndrome metabólico: preparación de un ensayo clínico. Mª Antonia Tascone Valle. 2016. Directoras: Jara Pérez Jiménez, Mª José Alfaro Calle. Universidad Complutense de Madrid, Facultad de Medicina.
  • Trabajo de Fin de Máster. Algas marinas como potenciales ingredientes funcionales. Evaluación del contenido y perfil de compuestos de interés nutricional y determinación de propiedades biológicas in vitro. Nerea Sanz Pintos,  2014. Directoras: Jara Pérez Jiménez, Mª Elisa Calle Purón. Universidad Complutense de Madrid, Facultad de Medicina

PATENTS

  • Method for producing a concentrate of polymer proanthocyanidins with a concentration of more than 40% by means of enzymatic treatments and without using organic solvents. WO 2017013299 A1. Inventores: Fulgencio Saura Calixto y Jara Pérez Jiménez.
  • Ingrediente antioxidante de bajo contenido calórico. Procedimiento de obtención y uso. Nº de solicitud PCT: PCT/ES2012/070885. Inventor: Fulgencio Saura Calixto
  • Natural grape antioxidant dietary fiber concentrate and its obtention method (CSIC). nº 9702397. Application Nº P9702397 Inventors: Fulgencio Saura-Calixto and José A Larrauri Garcia
  • Dietary fiber containing galactomannans. Application Nº P9800202 (CSIC-Granero Integral SL)Industrial exploitation :”Fiber-Gram, fibra dietética en cápsulas y pastillas para uso como suplemento dietético y en regímenes especiales. Inventors: Fulgencio Saura-Calixto, Laura Bravo Clemente, Isabel Goñi Cambrodon and Nuria Martin Carron.
  • Antioxidant dietary fiber and natural Fucus seaweed antioxidant concentrated and their obtention procedures. Application Nº P200002514. Inventors: Fulgencio Saura-Calixto and Antonio Jimenez-Escrig.
  • Antioxidant dietary fiber and concentrate of natural antioxidants aof skin and pulp of guava (Psidium guajava y Psidium acutangulum) and their obtention procedures . Application Nº P 200002515. Inventors: Fulgencio Saura-Calixto amd Antonio Jimenez-Escrig.
  • Antioxidant dietary fiber containing Phyllium and / or soluble dietary fiber. Application Nº P 200401440. Inventors: Fulgencio Saura-Calixto and Antonio Jimenez-Escrig.
  • Wine or wine products enriched in phenolic compounds and antioxidant capacity. Application Nº P200402615. Inventors: Fulgencio Saura-Calixto.
  • Functional formulation based on antioxidant dietary fiber and soluble dietary fiber. Application Nº P200401440. Inventors: Fulgencio Saura-Calixto and Isabel Goñi Cambrodon.
  • Procedure for obtaining olive oil and at least one multifunctional ingredient from olive. Application Nº P201131442Inventors: Fulgencio Saura-Calixto and María Elena Diaz-Rubio.